Claudins upregulation in human colorectal cancer

Emerging Roles of Claudins in Human Cancer

Claudins are major integral membrane proteins of tight junctions. Altered expression of several claudin proteins, in particular claudin-1, -3, -4 and -7, has been linked to the development of various cancers. Although their dysregulation in cancer suggests that claudins play a role in tumorigenesis, the exact underlying mechanism remains unclear. The involvement of claudins in tumor progression...

The frequency of human papillomaviruses and Epstein–Barr virus in colorectal cancer samples in Algeria

Background: environmental factors may play a role in colon cancer. In this view, several studies investigated tumor samples for the presence of various viral DNA with conflictiong results.  The purpose of this study is to investigate the prevalence of Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) in patients with colorectal carcinomas. Materials and methods: In this  study, we co...

The Anticancer Effects of Sargassum Boveanum Hydroalcoholic Extract in Human Colorectal Cancer Cell Lines

Background: Colorectal cancer (CRC) is one of the leading causes of death worldwide. Sargassum boveanum is a plant species of brown algae that is widely found in the Persian Gulf. The present study investigated the antioxidant and cytotoxic activity of the hydroalcoholic extract of Sargassum boveanum in colorectal cancer cell lines. Materials and Methods: Sargassum boveanum was collected from t...

Upregulation of TLRs and IL-6 as a Marker in Human Colorectal Cancer

Toll-like receptors (TLRs) not only form an important part of the innate immune system but also serve to activate the adaptive immune system in response to cancer. Real-time PCR; immunohistochemical stain and Western blotting analyses were performed to clarify molecular alterations in colorectal cancer (CRC) patients. We identified Toll-like receptor 1 (TLR1), TLR2, TLR4 and TLR8 gene expressio...

Claudins in Normal and Lung Cancer State